BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α
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چکیده
منابع مشابه
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha.
Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (BI-1) is an evolutionarily conserved ER-resident protein that suppresses cell death. Here we have investigated the role of BI-1 in the UPR. BI-1 expression suppressed IRE1alpha activity in fly and mouse models of ER...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2009
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2009.02.017